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This family contains just one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was found to methylate, moreover histone, a number of non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear issue kappaB (NFκB), and components of the TATA binding protein (TBP) complicated, TBP-related components TAF10 and TAF7 ninety three The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Okay/R-S/T-Okay (target lysine is bold), is also recognized by the H3K4 demethylase KDM1A/LSD1, which is capable of removing the methyl mark on most of these substrates 17 , 94 Due to this fact KMT7/KDM1A has emerged as a classic model for dynamic lysine methylation of each histone and non-histone proteins.
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Widespread posttranslational modifications embrace methylation of the ε-amino group, giving methyl- , dimethyl- , and trimethyllysine The latter occurs in calmodulin Other posttranslational modifications at lysine residues embrace acetylation , sumoylation , and ubiquitination Collagen comprises hydroxylysine , which is derived from lysine by lysyl hydroxylase - Glycosylation of hydroxylysine residues within the endoplasmic reticulum or Golgi equipment is used to mark certain proteins for secretion from the cell In opsins like rhodopsin and the visible opsins (encoded by the genes OPN1SW , OPN1MW , and OPN1LW ), retinaldehyde varieties a Schiff base with a conserved lysine residue, and interplay of light with the retinylidene group causes sign transduction in shade imaginative and prescient (See visual cycle for details).
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